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Tocris Bioscience™ Ac-Cys-NHMe

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Quantity:
10 mg
50 mg
Description
Ac-Cys-NHMe is a non-canonical amino acid that is an essential building block for lysine acylation using conjugating enzymes (LACE) technique. LACE is a chemoenzymatic approach that uses an E2 small ubiquitin-like modifier (SUMO)-conjugating enzyme, Ubc9, to conjugate peptide thioesters containing a C-terminal ubiquitin-derived sequence (LRLRGG) to a lysine residue located in a recognition sequence (IKQE) on a protein via an isopeptide bond. Ac-Cys-NHMe can be reacted with a peptide hydrazide to form a reactive peptide thioester, which is the substrate for Ubc9. LACE enables the site-specific modification of proteins at lysine residues to allow attachment of biochemical probes such as fluorophores to proteins or to engineer proteins for site-specific delivery.
Specifications
Specifications
Chemical Name or Material | (2R)-2-(Acetylamino)-3-mercapto-N-methylpropanamide |
CAS | 10061-65-1 |
Quantity | 50 mg |
Target | Unnatural Amino Acids |
Molecular Formula | C6H12N2O2S |
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