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ACBD3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. p-7205794 Shop All Proteintech Group Inc Products
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50-172-9208 150 μL
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Catalog No. 50-172-9208 Supplier Proteintech Group Inc Supplier No. 140961AP150UL
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Description

Rabbit Polyclonal Antibody

GOLPH1, also known as GCP60, was initially identified as a Golgi protein that can interact with the integral membrane protein giantin and is thought to be involved in the maintece of the Golgi structure. GOLPH1 has also been shown to interact with other Golgi proteins such as Golgin-160, a Golgi protein that can be cleaved by caspases-2, -3, and -7, leading to the nuclear localization of Golgin-160. GOLPH1 interaction with the Golgin-160 fragments is stronger than that with the intact Golgin-160, with its interaction regulated by the oxidation state of Cys-463 within GOLPH1, suggesting that the nuclear localization of the caspase-cleaved Golgin-160 fragments is a highly coordinated event. GOLPH1 has also been found to interact with Numb, a cytosolic signaling protein that mediates asymetric cell division of neural progenitor cells to a daughter progenitor cell and a neuron, suggesting that Golgi fragmentation and reconstitution during the cell cycle differentially regulate Numb signaling through changes in GOLPH1 subcellular distribution and may couple cell fate with cell cycle progression.

Specifications

Antigen ACBD3
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.17 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ACBD3
Gene Accession No. Q7TNY6, Q8BMP6, Q9H3P7
Gene Alias ACBD3, GCP60, GOCAP1, Golgi phosphoprotein 1, Golgi resident protein GCP60, GOLPH1, PAP7
Gene Symbols Acbd3
Host Species Rabbit
Immunogen ACBD3 Fusion Protein Ag5228
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170760, 289312, 64746
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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