Alpha-2-macroglobulin Mouse anti-Human, Clone: 4B11F7, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 661261IG150UL

Catalog No. 50-173-6562

Description

Alpha 2-Macroglobulin (a2M), is a approximately 720-kDa homotetrameric glycoprotein composed of four identical approximately 180 kDa subunits. aAlpha 2M shares with other alpha-macroglobulins, like the complement components C3 and C4 and the pregcy zone protein PZP, an extraordinary binding capacity for a variety of ligands. This allows the alpha-macroglobulins to serve as humoral defense barriers against foreign peptides in the plasma. Alpha 2M interacts and captures virtually any proteinase, often referred to as a panprotease inhibitor. In the brain of Alzheimer′s disease (AD) patients, Alpha 2M also has been localized to diffuse amyloid plaques, supporting an important role for alpha 2M in AD etiopathology.

Specifications

• Antigen: Alpha-2-macroglobulin
• Classification: Monoclonal
• Concentration: 1.8 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P01023
• Gene Symbols: A2M
• Immunogen: Alpha-2-macroglobulin Fusion Protein Ag19245
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 4B11F7
• Conjugate: Unconjugated
• Gene: A2M
• Gene Alias: A2M, Alpha 2 M, alpha 2 macroglobulin, CPAMD5, FWP007, S863 7, alpha-2M
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 2
• Content And Storage: -20°C
• Form: Liquid