ACTH Antibody (CLIP/1418) - C-terminus - Azide and BSA Free, Novus Biologicals™

Catalog No.	Quantity
NB013619	100 μg

Catalog No. NB013619 Supplier Novus Biologicals Supplier No. NBP280545

Description

Mouse Monoclonal Antibody

ACTH Monoclonal specifically detects ACTH in Human samples. It is validated for ELISA.

Specifications

• Antigen: ACTH
• Applications: ELISA
• Classification: Monoclonal
• Clone: CLIP/1418
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Dilution: ELISA 1:100-1:2000
• Formulation: 10 mM PBS
• Gene Alias: ACTH, adrenocorticotropic hormone, adrenocorticotropin, alpha-melanocyte-stimulating hormone, alpha-MSH, beta-endorphin, beta-LPH, beta-melanocyte-stimulating hormone, beta-MSH, CLIP, corticotropin-like intermediary peptide, corticotropin-lipotropin, gamma-LPH, gamma-MSH, lipotropin beta, lipotropin gamma, LPH, melanotropin alpha, melanotropin beta, melanotropin gamma, met-enkephalin, MSH, NPP, POC, pro-ACTH-endorphin, proopiomelanocortin, pro-opiomelanocortin, proopiomelanocortin preproprotein
• Gene Symbols: POMC
• Host Species: Mouse
• Immunogen: Synthetic peptide corresponding to aa25-39 of human ACTH (NGAEDESAEAFPLEF) (Uniprot: P01189)
• Purification Method: Protein A or G purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5443
• Test Specificity: ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This monoclonal antibody is specific to CLIP (aa25-39 of ACTH); does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. '
• Target Species: Human
• Content And Storage: Store at -20°C. Avoid freeze-thaw cycles.
• Form: Purified
• Isotype: IgG1 κ