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ACTH Antibody (SPM333), PE, Novus Biologicals™
SDP

Catalog No. NBP234761PE Shop All R&D Systems Products
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Description

Mouse Monoclonal Antibody

ACTH Monoclonal specifically detects ACTH in Human, Mouse, Rat samples. It is validated for Flow Cytometry.

Specifications

Antigen ACTH
Applications Flow Cytometry
Classification Monoclonal
Clone SPM333
Conjugate PE
Dilution Flow Cytometry
Gene Alias ACTH, adrenocorticotropic hormone, adrenocorticotropin, alpha-melanocyte-stimulating hormone, alpha-MSH, beta-endorphin, beta-LPH, beta-melanocyte-stimulating hormone, beta-MSH, CLIP, corticotropin-like intermediary peptide, corticotropin-lipotropin, gamma-LPH, gamma-MSH, lipotropin beta, lipotropin gamma, LPH, melanotropin alpha, melanotropin beta, melanotropin gamma, met-enkephalin, MSH, NPP, POC, pro-ACTH-endorphin, proopiomelanocortin, pro-opiomelanocortin, proopiomelanocortin preproprotein
Gene Symbols POMC
Host Species Mouse
Immunogen Synthetic peptide corresponding to aa1-24 of human ACTH (Uniprot: P01189)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Neuroscience, Nutrient Sensing in the Brain
Primary or Secondary Primary
Gene ID (Entrez) 5443
Test Specificity ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This monoclonal antibody is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. '
Target Species Human, Mouse, Rat
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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