ADAM10 Mouse anti-Human, Clone: 2A6B7, Proteintech

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-7038	Proteintech Group Inc 666201IG150UL	150 μL

Description

Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.

Specifications

• Antigen: ADAM10
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: AD10, ADAM 10, ADAM10, CD156c, CDw156, HsT18717, kuz, Kuzbanian protein homolog, MADM
• Gene Symbols: ADAM10
• Isotype: IgG1
• Purification Method: Protein G
• Product Type: Antibody

• Clone: 2A6B7
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: O14672
• Gene ID (Entrez): 102
• Immunogen: ADAM10 Fusion Protein Ag23062
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ADAM10