Tocris™ AEE 788

Potent EGFR and VEGFR inhibitor

Manufacturer: Tocris™ 5318/10

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Catalog No. 53-181-0

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For Research Use Only


    Product Type AEE 788
    Inhibitors AEE 788
    Purity >98
    Molecular Weight 440.58
    Quantity 10mg

    Potent EGFR and VEGFR inhibitor (IC50 values are 2, 6, 59, 77, 160 and 330nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC50 values are 52, 60 and 61nM respectively). Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro. Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice. Orally active.

    • Chemical Name: 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
    • Formula: C27H32N6
    • CAS Number: 497839-62-0
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

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