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Tocris Bioscience™ AEE 788

Potent EGFR and VEGFR inhibitor

Supplier:  Tocris Bioscience™ 5318/50

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Catalog No. 53-185-0


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Description

Description

AEE 788 is a potent EGFR and VEGFR inhibitor (IC50 values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC50 values are 52, 60 and 61 nM respectively). Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro. Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice. Orally active.
Specifications

Specifications

>98%
AEE 788
AEE 788
50 mg
440.58
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