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AF4 Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7141453
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Catalog No. Quantity
50-156-2370 20 μL
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Catalog No. 50-156-2370 Supplier Bethyl Laboratories, Inc Supplier No. A302344AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells.

Specifications

Antigen AF4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene AFF1
Gene Accession No. P51825
Gene Alias MIXED LINEAGE LEUKEMIA, TRANSLOCATED TO, 2, ALL1 FUSED GENE FROM CHROMOSOME 4, AF4, FEL
Gene Symbols AFF1
Host Species Rabbit
Immunogen Between 1 and 50
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4299
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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