AIRE Monoclonal Antibody (TM-724), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
14-953-495	LIFE TECHNOLOGIES 14953495	10 mg
14-953-482	LIFE TECHNOLOGIES 14953482	100 μg
14-953-437	LIFE TECHNOLOGIES 14953437	2 mg

Description

This TM-724 MAb reacts with human Autoimmune Regulator (AIRE). This 58 kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). AIRE mRNA in the periphery has been observed in the lymph node, fetal liver, and intestines. Furthermore expression has been observed in dendritic cells, epithelial cells and PBMCs. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation. As a result of alternative splicing, three isoforms have been reported. The conditions autoimmune-polyendocrinopathy-candiasis-ectodermal-dystrophy (APECED) and autoimmune polyglandular syndrome type 1 (APS-1) arise from mutations in the human AIRE gene. The TM-724 antibody is predicted to recognize all three isoforms of human AIRE (AIRE-1, AIRE-2, AIRE-3).

AIRE Monoclonal antibody specifically detects AIRE in Human samples. It is validated for Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)

Specifications

• Antigen: AIRE
• Concentration: 0.5 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Alias: AIRE; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
• Isotype: IgG2a κ
• Purification Method: Affinity chromatography
• Product Type: Antibody

• Clone: TM-724
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rat
• Target Species: Human
• Gene Accession No.: O43918
• Gene ID (Entrez): 326
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: Aire