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AKAP8/AKAP95 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No. 501559147
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50-155-9147 100 μL
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Catalog No. 50-155-9147 Supplier Bethyl Laboratories, Inc Supplier No. A301062A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predomitly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.

Specifications

Antigen AKAP8/AKAP95
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/ml
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene AKAP8
Gene Accession No. O43823, Q9DBR0
Gene Alias AKAP8; AKAP95; DKFZp586B1222; A kinase (PRKA) anchor protein 8; A kinase anchor protein 95; A-kinase anchor protein 8; A-kinase anchor protein, 95kDa
Gene Symbols AKAP8
Host Species Rabbit
Immunogen Between 642 and C-term
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10270, 56399
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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