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Invitrogen™ AKAP8 Polyclonal Antibody
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Catalog No. PIPA518265
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100 μg
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PIPA518265 100 μg
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Catalog No. PIPA518265 Supplier Invitrogen™ Supplier No. PA518265
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with bovine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AKAP8
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene AKAP8
Gene Accession No. O43823
Gene Alias 1200016A02Rik; A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; AA673585; AKAP 8; AKAP 95; Akap8; AKAP-8; Akap95; AKAP-95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; A-kinase anchoring protein 8; AU015639; DKFZp586B1222
Gene Symbols AKAP8
Host Species Goat
Immunogen Synthetic peptide sequence (DQGYGGYGAWSAG) corresponding to the N-terminus amino acids of AKAP8 (aa 2-15).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10270
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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