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ALK/CD246 Antibody (ALK/1503), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NP2437A70 Shop All R&D Systems Products
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NP2437A70 0.1 mL
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Catalog No. NP2437A70 Supplier Novus Biologicals Supplier No. NBP254375AF750
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Description

Mouse Monoclonal Antibody

ALK/CD246 Monoclonal specifically detects ALK/CD246 in Human samples. It is validated for Western Blot.

Specifications

Antigen ALK/CD246
Applications Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Clone ALK/1503
Conjugate Alexa Fluor 750
Dilution Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, anaplastic lymphoma kinase (Ki-1), anaplastic lymphoma receptor tyrosine kinase, CD246, CD246 antigen, EC 2.7.10.1, NBLST3
Gene Symbols ALK
Host Species Mouse
Immunogen Recombinant human ALK/CD246 protein fragment (aa1360-1460) (Uniprot: Q9UM73 )
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 238
Test Specificity The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This monoclonal antibody also reacts with blood vessels that serves as an internal positive control.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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