ALK Monoclonal Antibody (OTI2B3), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-8780	100 μL

Catalog No. 50-167-8780 Supplier OriGene Supplier No. TA801294

Description

Mouse Monoclonal Antibody

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3′ half of ALK, derived from chromosome 2, is fused to the 5′ portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.

Specifications

• Antigen: ALK
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2B3
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ALK
• Gene Accession No.: Q9UM73
• Gene Alias: CD246, NBLST3
• Gene Symbols: ALK
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1300-1620 of human ALK produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 238
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a