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Alkaline Phosphatase/ALPP Antibody (ALPP/516), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NP247991A70 Shop All R&D Systems Products
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Catalog No. NP247991A70 Supplier Novus Biologicals Supplier No. NBP247991AF750
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Description

Mouse Monoclonal Antibody

Alkaline Phosphatase/ALPP Monoclonal specifically detects Alkaline Phosphatase/ALPP in Human samples. It is validated for ELISA.

Specifications

Antigen Alkaline Phosphatase/ALPP
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunofluorescence
Classification Monoclonal
Clone ALPP/516
Conjugate Alexa Fluor 750
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias Alkaline phosphatase Regan isozyme, alkaline phosphatase, placental, alkaline phosphatase, placental (Regan isozyme), alkaline phosphatase, placental type, alkaline phosphomonoesterase, ALP, EC 3.1.3.1, FLJ61142, glycerophosphatase, PALP, Placental alkaline phosphatase 1, PLAP, PLAP-1, Regan isozyme
Gene Symbols ALPP
Host Species Mouse
Immunogen Recombinant full-length human Alkaline Phosphatase/ALPP protein (Uniprot: P05187)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cancer, Embryonic Stem Cell Markers, Ovarian Carcinoma Cell Markers, Phospho Specific, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 250.0
Test Specificity PLAP is a tissue specific, trophoblast-derived, 70kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+ metallo-glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific APs in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This monoclonal antibody binds equally well to all common allelic variants (S, F, FS and I) of PLAP and to some variants of AP from normal human testis. This monoclonal antibody can be used as tracer antibody in ELISA to detect PLAP in serum of S, F, FS and I phenotypes.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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