Alkaline Phosphatase, Tissue Non-Specific Antibody (SPM372), DyLight 594, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP247995DL594

Catalog No. NB007577

Description

Alkaline Phosphatase, Tissue Non-Specific Monoclonal specifically detects Alkaline Phosphatase, Tissue Non-Specific in Human, Bovine samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen, Immunofluorescence.

Specifications

• Antigen: Alkaline Phosphatase, Intestinal
• Classification: Monoclonal
• Conjugate: DyLight 594
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: ALPI
• Immunogen: Bovine alkaline phosphatase (Uniprot: P05186)
• Quantity: 0.1 mL
• Research Discipline: Cancer, Lipid and Metabolism, Ovarian Carcinoma Cell Markers, Phospho Specific, Protein Phosphatase, Stem Cell Markers
• Test Specificity: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
• Content And Storage: Store at 4°C in the dark.

• Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunofluorescence
• Clone: SPM372
• Dilution: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunofluorescence
• Gene Alias: alkaline phosphatase, intestinal, alkaline phosphomonoesterase, EC 3.1.3.1, glycerophosphatase, IAP, Intestinal alkaline phosphatase, intestinal-type alkaline phosphatase, Kasahara isozyme
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Primate
• Isotype: IgG1 κ