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Alkaline Phosphatase, Tissue Non-Specific Antibody (SPM372), Novus Biologicals™
SDP

Catalog No. NBP24496102 Shop All R&D Systems Products
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NBP24496102 0.2 mg
NBP24496100 0.02 mg
NBP24496101 0.1 mg
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Catalog No. NBP24496102 Supplier Novus Biologicals Supplier No. NBP2449610.2MG

Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence

Alkaline Phosphatase, Intestinal Monoclonal antibody specifically detects Alkaline Phosphatase, Intestinal in Human, Primate samples. It is validated for Flow Cytometry, Immunohistochemistry-Frozen, Immunofluorescence.

Specifications

Antigen Alkaline Phosphatase, Intestinal
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence
Classification Monoclonal
Clone SPM372
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. P05186, P05187, P05186, P05187
Gene Alias alkaline phosphatase, intestinal, alkaline phosphomonoesterase, EC 3.1.3.1, glycerophosphatase, IAP, Intestinal alkaline phosphatase, intestinal-type alkaline phosphatase, Kasahara isozyme
Gene Symbols ALPI
Host Species Mouse
Immunogen Bovine intestinal alkaline phosphatase
Molecular Weight of Antigen 55 kDa
Purification Method Protein A or G purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Cancer, Embryonic Stem Cell Markers, Lipid and Metabolism, Protein Phosphatase, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 248
Test Specificity There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Target Species Human, Primate
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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