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  6. Alkaline Phosphatase, Tissue Non-Specific Antibody (V17.1) - Azide and BSA Free, Novus Biologicals™

Alkaline Phosphatase, Tissue Non-Specific Antibody (V17.1) - Azide and BSA Free, Novus Biologicals™
SDP

Catalog No. NBP247996A Shop All R&D Systems Products
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NBP247996A 0.1 mg
NBP247996B 0.2 mg
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Catalog No. NBP247996A Supplier Novus Biologicals Supplier No. NBP2479960.1MG
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Description

Mouse Monoclonal Antibody

Alkaline Phosphatase, Tissue Non-Specific Monoclonal specifically detects Alkaline Phosphatase, Tissue Non-Specific in Human, Bovine samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunofluorescence, CyTOF-ready.

Specifications

Antigen Alkaline Phosphatase, Tissue Non-Specific
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence, CyTOF
Classification Monoclonal
Clone V17.1
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready
Formulation PBS with No Preservative
Gene Alias Alkaline phosphatase liver/bone/kidney isozyme, alkaline phosphatase, liver/bone/kidney, alkaline phosphatase, tissue-nonspecific isozyme, alkaline phosphomonoesterase, APTNAP, AP-TNAP, EC 3.1.3.1, FLJ40094, FLJ93059, glycerophosphatase, HOPS, liver/bone/kidney-type alkaline phosphatase, MGC161443, tissue-nonspecific ALP, TNAP, TNSALPMGC167935
Gene Symbols ALPL
Host Species Mouse
Immunogen Bovine intestinal alkaline phosphatase
Molecular Weight of Antigen 55 kDa
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 249
Test Specificity There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Target Species Human, Primate
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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