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alpha-Methylacyl-CoA Racemase/AMACR, Rabbit anti-Human, Janelia Fluor 646, Polyclonal, Novus Biologicals™
SDP

Catalog No. NB006104 Shop All R&D Systems Products
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NB006104 0.1 mL
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Catalog No. NB006104 Supplier Novus Biologicals Supplier No. NBP234514JF646

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit Polyclonal Antibody

alpha-Methylacyl-CoA Racemase/AMACR Polyclonal specifically detects alpha-Methylacyl-CoA Racemase/AMACR in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen alpha-Methylacyl-CoA Racemase/AMACR
Applications Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Janelia Fluor 646
Dilution Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias 2-methylacyl-CoA racemase, alpha-methylacyl-CoA racemase, CBAS4, EC 5.1.99.4, RACE, RM
Gene Symbols AMACR
Host Species Rabbit
Immunogen A synthetic peptide from human AMACR protein
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Lipid and Metabolism, Prostate Cancer, Signal Transduction
Primary or Secondary Primary
Test Specificity This antibody recognizes a protein of 54kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG
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