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Invitrogen™ alpha Synuclein Monoclonal Antibody (2A7)

Catalog No. PIMA547298
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500 μL
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PIMA547298 500 μL
PIMA547396 100 μL
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Catalog No. PIMA547298 Supplier Invitrogen™ Supplier No. MA547298
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Description

Mouse Monoclonal Antibody

alpha Synuclein Monoclonal Antibody for Western Blot, ICC/IF, IHC (PFA)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
TRUSTED_SUSTAINABILITY

Specifications

Antigen alpha Synuclein
Applications Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2A7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 5mM sodium azide
Gene SNCA
Gene Accession No. O55042, P37377, P37840, Q3I5G7, Q3T0G8
Gene Alias Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
Gene Symbols SNCA
Host Species Mouse
Immunogen Full length human recombinant protein expressed in and purified from E. coli.
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20617, 282857, 29219, 641350, 6622
Target Species Human, Mouse, Rat, Bovine, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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