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Invitrogen™ ALX3 Polyclonal Antibody
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Catalog No. PIPA5101076
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PIPA5101076 100 μL
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Catalog No. PIPA5101076 Supplier Invitrogen™ Supplier No. PA5101076
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ALX3.

Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predominant ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression. Alx3 (-) mice lack a phenotype distinct from wild-type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALX3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ALX3
Gene Accession No. O70137, O95076
Gene Alias ALX homeobox 3; ALX3; aristaless 3; aristaless-like homeobox 3; FND; FND1; frontonasal dysplasia; homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3
Gene Symbols ALX3
Host Species Rabbit
Immunogen A synthesized peptide derived from human ALX3(Accession O95076), corresponding to amino acid residues Q185-R235.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11694, 257, 365900
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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