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Invitrogen™ AMICA Polyclonal Antibody
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Catalog No. PIPA547491
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100 μg
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PIPA547491 100 μg
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Catalog No. PIPA547491 Supplier Invitrogen™ Supplier No. PA547491
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Description

Goat Polyclonal Antibody

In sandwich ELISAs, less than 0.3% cross-reactivity with recombinant mouse AMICA, recombinant human (rh) JAM-A, rhJAM-B, and rhJAM-C is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AMICA
Applications ELISA, Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene JAML
Gene Accession No. Q86YT9
Gene Alias adhesion molecule AMICA; adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; AMICA; Amica1; Crea7; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein Crea7; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Gm638; Jaml; junction adhesion molecule like; junctional adhesion molecule-like; mCrea7; UNQ722/PRO1387
Gene Symbols JAML
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human AMICA/JAML Leu20-Leu275.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 120425
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

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