Amphotericin B, Streptomyces nodosus

Description

Amphotericin B, CAS # 1397-89-3, is an antifungal that has been used against fungus caused by protozoan parasites of Leishmania genus. | CAS: 1397-89-3 | C47H73NO17 | 924.09 g/mol

Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Amphotericin B is an antibiotic that has antifungal activity and is produced mainly by Streptomyces nodosus

Applications

• It has antifungal activity against fungus caused by protozoan parasites of Leishmania genus by binding to an essential component of the fungal cell membrane and altering cell membrane permeability
• It can suppress bone marrow progenitor cells and induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro

Specifications

Chemical Identifiers

• CAS: 1397-89-3
• Molecular Formula: C47H73NO17
• Molecular Weight (g/mol): 924.09
• MDL Number: MFCD00877763
• InChI Key: APKFDSVGJQXUKY-ZNVUZQDLSA-N
• PubChem CID: 134129663
• IUPAC Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• SMILES: C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1O

• Type: Amphotericin B
• Physical Form: Powder
• Color: Yellow
• Quantity: 100 mg
• Sensitivity: Light and moisture sensitive
• Beilstein: 78342
• Merck Index: 14,585
• Solubility Information: Soluble in aqueous buffers at pH 2;0 or 11;0; Insoluble at pH 6;0-7;0; Also soluble in DMSO or DMF
• Formula Weight: 924.1
• Chemical Name or Material: Amphotericin B, Streptomyces nodosus

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	215-742-2
RTECSNumber	BU2625000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only