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Androgen R/NR3C4 Antibody (AR441 + DHTR/882), Biotin, Novus Biologicals™
SDP

Catalog No. NBP47857B Shop All R&D Systems Products
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NBP47857B 0.1 mL
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Catalog No. NBP47857B Supplier Novus Biologicals Supplier No. NBP247857B
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Description

Mouse Monoclonal Antibody

Androgen R/NR3C4 Monoclonal specifically detects Androgen R/NR3C4 in Human, Mouse (Negative) samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Androgen R/NR3C4
Applications Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone AR441 + DHTR/882
Conjugate Biotin
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation PBS with 0.05% Sodium Azide
Gene Alias AIS, androgen receptor, DHTRTFM, Dihydrotestosterone receptorHYSP1, HUMARA, NR3C4KD, Nuclear receptor subfamily 3 group C member 4, SMAX1SBMA, spinal and bulbar muscular atrophy
Gene Symbols AR
Host Species Mouse
Immunogen A synthetic peptide, aa 302-318 of human Androgen R/NR3C4 (Androgen R/NR3C4441); Recombinant human DHTR protein (DHTR/882) (Uniprot: P10275)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Breast Cancer, Cancer, Cellular Markers, Phospho Specific
Primary or Secondary Primary
Gene ID (Entrez) 367
Test Specificity Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This monoclonal antibody is superb for staining of formalin/paraffin tissues.
Target Species Human, Mouse (Negative)
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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