Adaptin α Mouse, Unlabeled, Clone: 8, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB610501	BD Biosciences 610501	50 μg
BDB610502	BD Biosciences 610502	150 μg

Description

Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins (α, γ, δ, or ε and β1, β2, β3 or β4, respectively) that are noncovalently linked to one medium chain (μ1, μ2, μ3 or μ4) and one small chain (σ1, σ2, σ3 or σ4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. In the AP-2 complex, Adaptin α is expressed in two very similar isoforms from two different genes. Adaptin α [A] (112kDa) is expressed primarily in brain, while Adaptin α [C] (105kDa) is expressed in brain, liver and other tissues.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: Adaptin α
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG1
• Purification Method: Affinity Purified

• Clone: 8
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Canine, Human, Mouse, Rat
• Immunogen: Mouse Adaptin α [A] aa. 38-215
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.