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Adaptin α Mouse, Unlabeled, Clone: 8, BD

Mouse Monoclonal Antibody

$232.00 - $427.00

Specifications

Antigen Adaptin α
Isotype IgG1
Immunogen Mouse Adaptin α [A] aa. 38-215
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610501
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BD Biosciences
610501
50μg
Each for $232.00
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BDB610502
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BD Biosciences
610502
150μg
Each for $427.00
Add to cart
 
Description

Description

Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins (α, γ, δ, or ε and β1, β2, β3 or β4, respectively) that are noncovalently linked to one medium chain (μ1, μ2, μ3 or μ4) and one small chain (σ1, σ2, σ3 or σ4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. In the AP-2 complex, Adaptin α is expressed in two very similar isoforms from two different genes. Adaptin α [A] (112kDa) is expressed primarily in brain, while Adaptin α [C] (105kDa) is expressed in brain, liver and other tissues.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

Adaptin α
Mouse Adaptin α [A] aa. 38-215
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
8
250μg/mL
SDS
Product Certifications

For Research Use Only.

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