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AIM-1 Mouse, Unlabeled, Clone: 6, BD

Mouse Monoclonal Antibody

$225.00 - $450.00

Specifications

Antigen AIM-1
Isotype IgG1
Immunogen Rat AIM-1 aa. 2-124
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611082
View Documents
BD Biosciences
611082
50μg
Each for $225.00
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BDB611083
View Documents
BD Biosciences
611083
150μg
Each for $450.00
Add to cart
 
Description

Description

The mitotic phase of the cell cycle is a complex process that ensures the fidelity of chromosome segregation. During the final stage of mitosis(telophase), segregated chromosomes become less condense and nuclear membranes surround the two sets of daughter chromosomes. Simultaneously, the separation and segregation of the cytoplasm (cytokinesis) ensures complete division and formation of two identical daughter cells. Regulation of cytokinesis is poorly understood and errors in this process can lead to cell death or oncogenesis. The Drosophila serine/threonine protein kinase Aurora and the S. cerevisiae Ipl1 kinase are highly homologous and are required for progression through mitosis. Their mammalian homolog AIM-1 (also known as Aurora and Ipl1-like midbody associated protein) accumulates at the G2/M interface. During late anaphase, AIM-1 is found at the equator of central spindles. However, during telophase and cytokinesis, it is found at the midbody. Although over-expression of a kinase-inactive AIM-1 mutant disrupts formation of the cleavage furrow, nuclear division is unaffected. Thus, it is thought that AIM-1 is essential for cleavage furrowing and the onset of cytokinesis.

Immunofluorescence, Western Blotting

Specifications

Specifications

AIM-1
Rat AIM-1 aa. 2-124
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Aurora B; Aurora and Ipl1-like midbody associated protein
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
6
250μg/mL
Store undiluted at -20°C.
SDS

For Research Use Only.

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