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Akt Mouse, Unlabeled, Clone: 55, BD

Mouse Monoclonal Antibody

$232.00 - $427.00

Specifications

Antigen Akt
Isotype IgG1, κ
Immunogen Human Akt1 Recombinant Protein
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610860
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BD Biosciences
610860
50μg
Each for $232.00
Add to cart
 
BDB610861
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BD Biosciences
610861
150μg
Each for $427.00
Add to cart
 
Description

Description

Akt [also known as PKB (Protein kinase B) or RAC-PK (Related to the A and C kinases] is a family of serine/threonine kinases that contains a pleckstrin homology (PH) domain. PH domains play important roles in signal transduction. There are three known isoforms of Akt in mammalian cells [Akt1 (α), Akt2 (β) and Akt3 (γ)]; they are thought to be regulated similarly. Akt is activated by insulin and growth factors by a mechanism involving phosphoinositide 3-OH kinase. Phosphoinositide 3-OH kinase products bind to the PH domain, resulting in translocation of Akt to the plasma membrane and activation of Akt to phospho-Akt by upstream kinases. Akt is phosphorylated within the activation loop at threonine 308 and the C-terminus at serine 473. Phospho-Akt promotes cell survival by inhibiting apoptosis. Specifically, phospho-Akt1 has been shown to phosphorylate Bad, a member of the Bcl-2 family that promotes cell death. This phosphorylation results in the inactivation of the proapoptotic function of Bad. The Akt molecule is thus considered to link extracellular survival signals (growth factors) with the apoptotic machinery (Bad). Akt is also a key mediator of the metabolic effects of insulin. Additionally, Akt has been referred to as an oncogene because it has increased activity in a number of tumors.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

Akt
Human Akt1 Recombinant Protein
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
PKBα, RAC-PK
IgG1, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
55
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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