MilliporeSigma™ anti-Amyloid Precursor Protein, C-Terminal (751-770), Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ 17161050UL

Catalog No. 17-161-050UL

Description

Specifically detects Amyloid Precursor Protein, C-Terminal (751-770) Clone: in Human samples, and it is validated for Immunofluorescence, Immunohistochemistry, Immunoprecipitation

Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP is cleaved by alpha-secretase to generate sAPPα and CTFα, which is the C-terminal membrane, associated product ofα-secretase cleavage.α-secretase cleaves in the Aβ domain.β-secretase cleavage of APP at the N-terminal end of the Aβ sequence results in sAPPβ and CTFβ. Both CTFα and CTFβ are cleaved at the C-terminal end of the Aβ transmembrane domain to generate CTFγ. The antibody (171610) detects CTFγ fragment, which migrates at about 6kDa on SDS-PAGE gels.

Specifications

• Antigen: Amyloid Precursor Protein, C-Terminal (751-770)
• Classification: Polyclonal
• Host Species: Rabbit
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Undiluted

• Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation
• Conjugate: Unconjugated
• Immunogen: a synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH
• Regulatory Status: RUO
• Test Specificity: Recognizes full-length APP and C-terminal soluble products CTFγ (∽6kDa), CTFα (∽9kDa), and CTFβ (∽11kDa). Antibody Target Gene Symbol: APP Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2 Entrez Gene Name: amyloid beta (A4) precursor protein
• Content And Storage: −20°C
• Isotype: IgG

For Research Use Only