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MilliporeSigma™ anti-Amyloid Precursor Protein, C-Terminal (751-770), Polyclonal

Catalog No. 17161050UL Shop All MilliporeSigma Products
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50 μL
Conjugate:
Unconjugated
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17-161-050UL 50 μL Unconjugated
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Catalog No. 17-161-050UL Supplier MilliporeSigma™ Supplier No. 17161050UL
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Description

Rabbit Polyclonal Antibody

Specifically detects Amyloid Precursor Protein, C-Terminal (751-770) Clone: in Human samples, and it is validated for Immunofluorescence, Immunohistochemistry, Immunoprecipitation

Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP is cleaved by alpha-secretase to generate sAPPα and CTFα, which is the C-terminal membrane, associated product ofα-secretase cleavage.α-secretase cleaves in the Aβ domain.β-secretase cleavage of APP at the N-terminal end of the Aβ sequence results in sAPPβ and CTFβ. Both CTFα and CTFβ are cleaved at the C-terminal end of the Aβ transmembrane domain to generate CTFγ. The antibody (171610) detects CTFγ fragment, which migrates at about 6kDa on SDS-PAGE gels.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Amyloid Precursor Protein, C-Terminal (751-770)
Applications Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
Host Species Rabbit
Immunogen a synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes full-length APP and C-terminal soluble products CTFγ (∽6kDa), CTFα (∽9kDa), and CTFβ (∽11kDa). Antibody Target Gene Symbol: APP Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2 Entrez Gene Name: amyloid beta (A4) precursor protein
Target Species Human
Content And Storage −20°C
Form Undiluted
Isotype IgG
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