Annexin VII Mouse anti-Human, Unlabeled, Clone: 5, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB610668	BD Biosciences 610668	50 μg
BDB610669	BD Biosciences 610669	150 μg

Description

Annexin VII, also known as synexin, is a member of the Annexin family characterized by Ca²⁺ dependent phospholipid binding. Annexins have a four-fold internal repeat of about 70 amino acids that contains the Ca²⁺-binding sites. They also have a regulatory NH2-terminal region of 30-40 amino acids. Annexin VII mRNA has been detected in many tissues and is most abundant in brain, heart, skeletal muscle, and lung. Annexin VII mRNA exhibits a tissue dependent polymorphism due to alternative splicing which results in two different isoforms of 47kDa and 51kDa. In vitro, Annexin VII aggregates chromaffin granules and enhances membrane fusion in a Ca²⁺ and GTP-dependent manner. Although the physiological role of Annexin VII is not completely understood, it is believed to influence and regulate Ca²⁺ dependent events such as secretion at the plasma membrane.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: Annexin VII
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Human
• Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Primary or Secondary: Primary

• Clone: 5
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG1
• Purification Method: Affinity Purified

For Research Use Only.