ApoA-1 Mouse anti-Rat, Unlabeled, Clone: 4, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612330
In blood, cholesterol and triglycerides are transported in lipoprotein particles that consist of a single layer of phospholipid surrounding a lipid core and surface-associated apolipoproteins (Apo). The Apo-proteins are involved in the specific binding of cellular receptors, the regulation of lipolytic enzymes, and the process of lipid exchange. High density lipoprotein particles (HDLs) contain the apolipoproteins ApoA-I, ApoA-II and Apo-M, whereas low density (LDL), intermediate density, and very low density (VLDL) lipoprotein particles contain ApoB-100 as the primary structural element. ApoA-I is synthesized in the liver and small intestines, where it acts as a cofactor for lecithin-cholesterol acyltransferase during the formation of cholesterol ester. ApoA-II is synthesized in the liver where it activates hepatic lipase. In HepG2 cells, treatment with gramoxone causes oxidative stress and reductions in ApoA-I mRNA levels. This down regulation of ApoA-I may contribute to reduced plasma HDL levels in response to oxidants, such as cigarette smoke. Thus, ApoA-I is an important cofactor fo cholesterol synthesis and is a major component of HDLs.
|Rat ApoA-I aa. 144-258|
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