ATP Synthase α Mouse, Unlabeled, Clone: 51, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB612516	BD Biosciences 612516	50 μg
BDB612517	BD Biosciences 612517	150 μg

Description

ATP synthase is a large enzyme complex that uses an electrochemical H+ or Na+ gradient to synthesize ATP from ADP and Pi, providing the organism with the ATP needed for energy. The complex consists of two major units, F0 and F1. F0 is embedded in the inner membrane of the mitochondria and, due to its hydrophobic nature, translocates protons across this membrane. F1 is the catalytic portion in the matrix region of the mitochondria and is comprised of α, β, γ, δ, and ε subunits at a 3:3:1:1:1 ratio. The α subunit is a ubiquitous protein that is highly conserved among species. It has an adenine specific binding site that binds both ATP and ADP. There are two glycine rich regions in the sequence, the A domain and B domain, that are thought to be part of the nucleotide binding domain. It has been demonstrated that the N-terminus of the α subunit is necessary for the correct functional and structural connection of F0 to F1. Thus, the α subunit is an essential component of the ATP synthase complex and plays a role in properly orienting the F0 and F1 units.

Immunofluorescence, Western Blotting

Specifications

• Antigen: ATP Synthase α
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG2a
• Purification Method: Affinity Purified

• Clone: 51
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Canine, Chicken, Human, Mouse, Rat
• Immunogen: Human ATP Synthase α aa. 113-220
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.