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BiP/GRP78 Mouse, Unlabeled, Clone: 40, BD

Mouse Monoclonal Antibody

$232.00 - $463.00

Specifications

Antigen BiP/GRP78
Isotype IgG2a
Immunogen Human BiP/GRP78 aa. 525-628
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610978
View Documents
BD Biosciences
610978
50μg
Each for $232.00
Add to cart
 
BDB610979
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BD Biosciences
610979
150μg
Each for $463.00
Add to cart
 
Description

Description

Synthesis of nascent proteins occurs at sites on the endoplasmic reticulum (ER) called translocons. Translocon proteins form a pore in the membrane that allow passage of the newly synthesized protein from the ribosome into the ER lumen. As the nascent protein enters the lumen, it is bound by BiP ( bi nding p rotein), the major chaperone of the ER. This protein is identical to the 78kDa glucose regulated protein, GRP78. BiP binds short hydrophobic sequences of the emerging peptide and prevents denaturation or nonspecific aggregation. Hydrolysis of ATP by BiP results in the release of the nascent protein which quickly assumes its proper conformation. However, if folding is incorrect, BiP again binds the protein and prevents its exit from the ER. In addition, BiP binding is thought to enhance the movement of secretory polypeptides across the ER membrane, but it is not required for protein translocation. It is 60% identical to Hsp70 and is similarly increased by conditions that produce incorrectly folded proteins. Thus, BiP is a chaperone of the ER lumen that binds misfolded or unassembled secretory proteins and ensures proper movement of proteins from the ER to the Golgi apparatus.
Specifications

Specifications

BiP/GRP78
Human BiP/GRP78 aa. 525-628
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
GRP78
IgG2a
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
40
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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