c-Myc with control Mouse anti-Human, Unlabeled, Clone: 9E10., BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB551101	BD Biosciences 551101	50 μg
BDB551102	BD Biosciences 551102	150 μg

Description

The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation. C-myc migrates at 62 kDa in SDS-PAGE. Clone 9E10 recognizes human c-myc. A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.

Specifications

• Antigen: c-Myc with control
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Isotype: IgG1
• Purification Method: Affinity Purified

• Clone: 9E10.
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.