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CD104 Rat anti-Mouse, Unlabeled, Clone: 346-11A, BD

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Description

Rat Monoclonal Antibody

The 346-11A antibody reacts with an epitope at the beginning of the cysteine-rich repeat region of the 200-kDa integrin β 4 chain (CD104), which is found on the cell surface as a heterodimeric complex with the integrin α 6 chain (CD49f). The α 6β 4 complex binds to laminins and is expressed on the basal surface of a variety of epithelial cell types, particularly on stratified squamous epithelia, and is also found in peripheral nerves, in certain subsets of endothelial cells, and on immature thymocytes. It has also been identified on a number of tumor tissues and participates in tumor progression events. Because of the localization of both human and mouse epidermal α 6β 4 integrin to hemidesmosomes, a role in epidermal adhesion to basement membrane has been suggested.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD104
Applications Flow Cytometry
Classification Monoclonal
Clone 346-11A
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Integrin β4 chain
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Tumor-associated antigen TSP-180 from a BALB/c mouse lung carcinoma
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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