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CD104 Rat anti-Mouse, Unlabeled, Clone: 346-11A, BD
Rat Monoclonal Antibody
Supplier: BD Biosciences 553745
Description
The 346-11A antibody reacts with an epitope at the beginning of the cysteine-rich repeat region of the 200-kDa integrin β 4 chain (CD104), which is found on the cell surface as a heterodimeric complex with the integrin α 6 chain (CD49f). The α 6β 4 complex binds to laminins and is expressed on the basal surface of a variety of epithelial cell types, particularly on stratified squamous epithelia, and is also found in peripheral nerves, in certain subsets of endothelial cells, and on immature thymocytes. It has also been identified on a number of tumor tissues and participates in tumor progression events. Because of the localization of both human and mouse epidermal α 6β 4 integrin to hemidesmosomes, a role in epidermal adhesion to basement membrane has been suggested.

Specifications
CD104 | |
Monoclonal | |
0.5mg/mL | |
Integrin β4 chain | |
Rat | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at 4°C |
Flow Cytometry | |
346-11A | |
Unconjugated | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
Tumor-associated antigen TSP-180 from a BALB/c mouse lung carcinoma | |
0.5 mg | |
Immunology | |
Mouse | |
IgG2a κ |
Safety and Handling
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For Research Use Only.