CD105 (Endoglin) Mouse anti-Human, PE, Clone: 266, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 560839

Catalog No. BDB560839

Description

The 266 monoclonal antibody specifically binds to CD105. CD105 presents an integral membrane homodimer protein with subunits of 95 kDa found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on U937 cells, activated macrophages, and mesenchymal stem cells. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and TGF-β3 with high affinity but does not bind toTGF-β2. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

Specifications

• Antigen: CD105
• Classification: Monoclonal
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human Umbilical Vein Endothelial Cells
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 266
• Description: Endoglin; ENG; END; HHT1; ORW; ORW1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ