CD154 Mouse anti-Human, APC, Clone: TRAP1, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB560955	BD Biosciences 560955	25 Tests
BDB555702	BD Biosciences 555702	100 Tests

Description

Reacts with CD40 ligand (CD40L), a 39kDa type II membrane glycoprotein expressed on activated T cells. CD40-CD40L interaction plays a very important role in T cell-dependent B-cell proliferation, differentiation, and memory cell formation. Anti-CD40L mAb partially blocks T cell-B cell interaction affecting subsequent proliferation, differentiation, and memory cell formation. Anti-CD40L mAb partially blocks T cell-B cell interaction affecting subsequent proliferation, IL-2R expression and differentiation of B cells. In addition, blocking of CD40-CD40L interaction has been demonstrated with soluble CD40, resulting in the inhibition of immunoglobulin isotype switching. It has been reported that patients with X-linked hyper-IgM syndrome have defective expression of functional CD40L due to a defective gene that encodes CD40L. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: TRAP1
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: CD154
• Applications: Flow Cytometry
• Conjugate: APC
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Clone: TRAP1
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Baboon, Cynomolgus, Human, Rhesus Monkey
• Isotype: IgG1 κ
• Purification Method: Affinity Purified
• Description: CD40LG; CD40 ligand; CD40L; TNFSF5; T-BAM; TRAP

For Research Use Only.