anti-CD3zeta/T Cell Receptor zeta Ab-8, Clone: 6B10, Epredia™ LabVision

Mouse Monoclonal Antibody

Supplier:  Epredia MS1289P1

Catalog No. MS1289P1

Description

CD3 consists of five different polypeptide chains (designated as γ, δ, ε, ζ, and η). The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). It is involved in signal transduction to the T cell interior following antigen recognition, which culminates in cytokine release, cellular proliferation.. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

Host Species: Mouse
Clone: 6B10
Isotype: IgG1
Cross Reactivity: Human, Mouse, and Rat. Others-not tested.
Epitope: aa 36-54 of T Cell Receptor zeta Chain
Immunogen: Synthetic peptide corresponding to aa 36-54 of T Cell Receptor ζ Chain.
Molecular Weight: ∽20kDa
Positive Control: Jurkat cells.
Cellular Localization: Cell membrane

Ab-8 reacts with phosphorylated and unphosphorylated forms of of T Cell Receptor zeta Chain. It co-immunoprecipitates the zeta chain associated tyrosine kinase ZAP-70

Immunoprecipitation, Western Blotting

Specifications

• Antigen: CD3ζ/T Cell Receptor ζ Ab-8
• Concentration: 200μg/mL
• Host Species: Mouse
• Purification Method: Jurkat cells
• Primary or Secondary: Primary
• Content And Storage: 2–8 degrees
• Isotype: IgG1

• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Synthetic peptide corresponding to aa 36-54 of T Cell Receptor ζ Chain.
• Quantity: 500 μL
• Target Species: Human, Mouse, Rat
• Form: Purified