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Invitrogen™ CD46 Monoclonal Antibody (MEM-258), Biotin
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Catalog No. 01676254
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Catalog No. Quantity
01-676-254 100 μg
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Catalog No. 01-676-254 Supplier Invitrogen™ Supplier No. MA119520
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.

CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD46
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone MEM-258
Concentration 1 mg/mL
Conjugate Biotin
Formulation PBS with 15mM sodium azide; pH 7.4
Gene CD46
Gene Accession No. P15529, Q6VE48
Gene Alias AHUS2; antigen identified by monoclonal antibody TRA-2-10; brain microvascular membrane cofactor; brain microvascular membrane cofactor protein CD46; Cd46; CD46 antigen, complement regulatory protein; CD46 complement regulatory protein; CD46 molecule; CD46 molecule, complement regulatory protein; CD46 splice variant; complement membrane cofactor protein; complement regulatory protein; Mcp; MCP; complement activation regulator; measles virus receptor; membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); membrane cofactor protein variant 10; membrane cofactor protein variant 7; membrane cofactor protein variant 8; membrane cofactor protein variant 9; MGC26544; MIC10; soluble membrane cofactor protein variant 11; soluble membrane cofactor protein variant 12; soluble membrane cofactor protein variant 13; TLX; TRA2.10; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
Gene Symbols CD46
Host Species Mouse
Immunogen T cell line HPB-ALL.
Purification Method Size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 280851, 4179
Target Species Human, Bovine
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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