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CD49b Mouse anti-Human, Unlabeled, Clone: 2, BD

Mouse Monoclonal Antibody

$207.00 - $415.00

Specifications

Antigen CD49b
Isotype IgG2a
Immunogen Human VLA-2α aa.42-245
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611016
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BD Biosciences
611016
50μg
Each for $207.00
Add to cart
 
BDB611017
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BD Biosciences
611017
150μg
Each for $415.00
Add to cart
 
Description

Description

Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large α chain that is non-covalently associated with a smaller β chain which is used to define integrin subfamilies. These molecules exhibit a wide range of expression throughout development and adulthood. VLA-2 (very late antigen), a member of the integrin superfamily, was identified on activated T cells, but has since been reported to be on various cell types. VLA-2 is reported to be a heterodimer of integrin α2 (CD49b) and integrin β1 (CD29) subunits. The α2 chain contains a large extracellular domain, a transmembrane domain, and a short cytoplasmic tail. VLA-2 functions as a collagen receptor on platelets and fibroblasts, as well as a collagen and laminin receptor on endothelial and epithelial cells. On activated T cells, VLA-2, like LFA-1, exhibits increased number and affinity of ligand binding. Interactions of these molecules with their extracellular matrix ligands is important for directing effector T cells to their target tissues and to provide co-stimulatory signals. Thus, VLA-2 not only plays an important role in cellular adhesion, but may function in intracellular signal transmission.

Immunofluorescence, Western Blotting

Specifications

Specifications

CD49b
Human VLA-2α aa.42-245
Unconjugated
Immunology
Murine
Affinity Purified
Monoclonal
Integrin α2; VLA-2α
IgG2a
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
2
250μg/mL
Store undiluted at -20°C.
SDS

For Research Use Only.

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