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CD49F Rat anti-Human, Brilliant Violet 650, Clone: GOH3, BD

Rat Monoclonal Antibody

$201.00 - $396.00

Specifications

Antigen CD49f
Isotype IgG2a, κ
Immunogen Mouse mammary tumor cells
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Conjugate Brilliant Violet 650
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Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB563706
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BD Biosciences
563706
25 Tests
Each for $201.00
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BDB563707
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BD Biosciences
563707
100 Tests
Each for $396.00
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Description

Description

The GoH3 monoclonal antibody specifically binds to CD49f which is also known as i ntegrin α6 chain . CD49f is a ∽150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The i ntegrin α6 subunit associates with the i ntegrin β1 chain (CD29) to form VLA-6 and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is ex pressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of placenta. GoH3 recognizes an extracellular epitope of integrin α6 on human, mouse and bovine cells. GoH3 has been reported to block the binding of integrin α6 to laminin P1 and E8 fragments.

The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. This dye is a tandem fluorochrome of BD Horizon™ BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 650-nm. BD Horizon™ BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination.

Specifications

Specifications

CD49f
Mouse mammary tumor cells
Brilliant Violet 650
Flow Cytometry
RUO
GOH3
ITGA6; IThe GoH3 monoclonal ntegrin alpha-6; Integrin α6 chain; VLA-6; ITA6
IgG2a, κ
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Primary
Rat
Affinity Purified
Monoclonal
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
SDS
Product Certifications

For Research Use Only.

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