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CD63 Mouse anti-Human, Clone: MEM-259, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119281

Catalog No. 01-676-037


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Description

Description

CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.
Specifications

Specifications

CD63
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P08962
LAMP-3, ME491, MLA1, OMA81H, TSPAN30
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
967
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
MEM-259
Unconjugated
CD63
Liquid
CD63
T cell line HPB-ALL.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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