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CD71 Mouse anti-Human, APC-H7, Clone: M-A712, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563671

Catalog No. BDB563671


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Description

Description

The M-A712 monoclonal antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR). This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers. CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells. CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin. After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surface.

Specifications

Specifications

CD71
M-A712
TFR; TFRC; Trfr; TfR1; Transferrin receptor protein 1
Affinity Purified
T-CLL and Jurkat Cells
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
APC-H7
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Murine
IgG2a, κ
RUO
Primary
Human
Documents
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