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CD71 Mouse anti-Human, APC-H7, Clone: M-A712, BD

Catalog No. BDB563671 Shop All BD Biosciences Products
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BDB563671 100 Tests
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Description

Mouse Monoclonal Antibody

The M-A712 monoclonal antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR). This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers. CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells. CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin. After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surface.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD71
Applications Flow Cytometry
Classification Monoclonal
Clone M-A712
Conjugate APC-H7
Description TFR; TFRC; Trfr; TfR1; Transferrin receptor protein 1
Host Species Mouse
Immunogen T-CLL and Jurkat Cells
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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