CD80 Mouse anti-Human, V450, Clone: L307.4, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB560444	BD Biosciences 560444	30 Tests
BDB560442	BD Biosciences 560442	120 Tests

Description

Reacts with B7/BB1, a 60kDa transmembrane glycoprotein which was clustered as CD80 in the Fifth International Workshop on Human Leukocyte Differentiation Antigens. CD80, a member of the Ig supergene family, is expressed on activated B cells, macrophages, and dendritic cells. It is the ligand for two molecules expressed on T cells, CD28 and CD152 (CTLA-4). CD80 is also expressed on activated CD4+ and CD8+ T cells, appearing late after activation suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway. The binding of CD28 by anti-CD28 or by CD80 results in T-cell activation and a signal for IL-2 production. The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is available exclusively from BD Biosciences. It is excited by the Violet laser Ex max of 406nm and has an Em Max at 450nm. Conjugates with BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates.

Host Species: Mouse
Clone: L307.4
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: CD80
• Applications: Flow Cytometry
• Conjugate: Violet Fluor 450 (V450)
• Regulatory Status: RUO
• Target Species: Human
• Immunogen: Human B7-transfected L cells
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Clone: L307.4
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Immunology
• Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
• Isotype: IgG1 κ
• Purification Method: Affinity Purified
• Description: B7.1; B7-1; Activation B7-1 antigen; B7; BB1; CD28LG; CD28LG1; LAB7

For Research Use Only.