Ubiquilin 4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520781
A suggested positive control is NIH-3T3 cell lysate. PA5-20781 can be used with blocking peptide PEP-0895.The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.
|An 18 amino acid peptide near the amino terminus of human CIP75.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-336K24.8, A1U, C1orf6, CIP75, UBIN; ataxin-1 ubiquitin-like interacting protein; ataxin-1 ubiquitin-like-interacting protein A1U; ubiquilin-4|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|310633, 56893, 94232|
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