Crk Mouse, Unlabeled, Clone: 22, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610036

Catalog No. BDB610036

Description

Crk was first isolated as the v- crk oncogene from chicken retroviruses CT10 and ASV-1. All human cell lines examined to date express a 40 kDa Crk protein. In addition, there is variable expression of 42 kDa and 28 kDa Crk proteins. The c- crk gene is one of a class of genes, such as Nck and GRB2/ASH , which encode proteins that consist mainly of SH2 and SH3 domains. These proteins function as adaptor molecules in tyrosine kinase signal transduction pathways. The SH2 domains interact with phosphotyrosine-containing peptides, while the SH3 domains can enhance this interaction and/or bind to other cellular components. Both the SH2 and SH3 domains of the human Crk protein are required for differentiation of PC12 cells. Thus, Crk has a role in an NGF-induced signaling pathway that involves activation of p21ras. Furthermore, three proteins of 118 kDa, 125 kDa, and 136 kDa which specifically bind to the Crk SH3 domain have been identified.

Specifications

• Antigen: Crk
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Human Crk aa. 102 to 304
• Quantity: 150 μg
• Research Discipline: Cell Biology
• Target Species: Bovine, Canine, Chicken, Frog, Human, Mouse, Rat
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 22
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.