Cyclin E Mouse anti-Human, Unlabeled, Clone: HE12, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB551159	BD Biosciences 551159	50 μg

Description

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small proteins that bind to cyclins, cdks, or cyclin-cdk complexes, e.g., p21 and p27 [Kip1]. Cyclin E is expressed in G1 and associates with cdk2 to form an active kinase where it plays an important role in the regulation of the G1/S restriction checkpoint in the cell cycle. Abberant expression of cyclin E has been reported to be associated with the oncogenic transformation of cells. This antibody has been reported not to cross-react with mouse cyclin E.

Specifications

• Antigen: Cyclin E
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Human
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Clone: HE12
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Isotype: IgG1
• Purification Method: Affinity Purified

For Research Use Only.