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Disabled-2/p96 Mouse, Unlabeled, Clone: 52, BD

Mouse Monoclonal Antibody

$226.00 - $448.00

Specifications

Antigen Disabled-2/p96
Isotype IgG1
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610465
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BD Biosciences
610465
150μg
Each for $448.00
Add to cart
 
BDB610464
View Documents
BD Biosciences
610464
50μg
Each for $226.00
Add to cart
 
Description

Description

CSF-1 is a growth factor that stimulates the growth and differentiation of immature lymphocytes and is required for the survival of mononuclear phagocytes. Binding of CSF-1 induces dimerization and autophosphorylation of its receptor. This results in the activation of several signal transduction pathways. A unique 96 kDa protein is a component in the CSF-1 signal transduction cascade. p96 is phosphorylated on serine following mitogenic stimulation of a mouse macrophage cell line. p96 contains three potential C-terminal ERK kinase phosphorylation sites, as well as several proline-rich sequences that are potential binding sites for SH3-containing proteins. Structural similarities have been found between p96 and Dab, a product of the Drosophila disabled gene, and p96 was also identified as Disabled-2 (Dab-2) and as differentially expressed in ovarian β receptor to the Smad family of transcription factors. Thus, Dab-2/p96 is an important adaptor molecule in growth factor signaling pathways.

Specifications

Specifications

Disabled-2/p96
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Disabled-2
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
52
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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