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DLP1 Mouse, Unlabeled, Clone: 8, BD

Catalog No. BDB611113 Shop All BD Biosciences Products
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Description

Mouse Monoclonal Antibody

Dynamins, phosphoproteins with intrinsic GTPase activities, play an important role during early endocytosis. The GTPase activity is stimulated in vitro by microtubules, SH3 domain containing-proteins, and Protein Kinase (PKC)- mediated phosphorylation. Although highly related, dynamins are differentially expressed in an organism. For instance, dynamin I is found only in the nervous system, dynamin II is ubiquitously expressed, and dynamin III is located in lung, testis and brain. Due to four alternative splicing products for each of the dynamins, the dynamin family contains at least 12 different members. The Dynamin Like Protein-1 (DLP1) is a new member of the dynamin family of proteins. DLP1 (also known as DVLP) is widely expressed as two alternatively spliced products, each with different tissue expression patterns. The larger product is about 84kDa and reportedly found only in the brain, whereas the 79kDa product is ubiquitously expressed. Unlike dynamins I-III which co-localize with endocytotic vesicles, DLP1 is found aligned with microtubules and with the endoplasmic reticulum, suggesting a secretory function for this novel protein.

Host Species: Mouse
Clone: 8
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat DLP1 aa. 601-722
Formula Weight [Chemical]: 79-84kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen DLP1
Applications Western Blot
Classification Monoclonal
Clone 8
Concentration 250μg/mL
Conjugate Unconjugated
Description Dynamin Like Protein-1; DVLP
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat DLP1 aa. 601-722
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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