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E-Cadherin Mouse, FITC, Clone: 36/E-CADHERIN, BD

Mouse Monoclonal Antibody

$207.00 - $394.00

Specifications

Antigen E-Cadherin
Isotype IgG2a, κ
Immunogen Human E-Cadherin aa. 735-883
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate FITC
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612130
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BD Biosciences
612130
50μg Each for $207.00
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BDB612131
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BD Biosciences
612131
150μg Each for $394.00
Add to cart
 
Description

Description

E-Cadherin is a 120kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation

Specifications

Specifications

E-Cadherin
Human E-Cadherin aa. 735-883
FITC
Cell Biology
Murine
Affinity Purified
Monoclonal
CD324; CDH1; CADH1; Cadherin-1; ECAD; CDHE; Arc-1; LCAM; UVO; Uvomorulin
IgG2a, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Immunofluorescence
RUO
36/E-CADHERIN
250μg/mL
Store undiluted at -20°C.

For Research Use Only.

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