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MilliporeSigma™ anti-GAPDH Clone: 6C5,

Catalog No. CB1001500UG Shop All MilliporeSigma Products
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Quantity:
500 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
CB1001500UG 500 μg Unconjugated
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Catalog No. CB1001500UG Supplier MilliporeSigma™ Supplier No. CB1001500UG
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Description

Mouse Monoclonal Antibody

Specifically detects GAPDH Clone: 6C5 in Canine, Chicken, Fish, Frog, Human, Mouse, Porcine, Rabbit, Rat samples, and it is validated for ELISA, Immunocytochemistry, Immuno Blotting

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is one of the key enzymes involved in glycolysis. GAPDH is comprised of four ∽36kDa subunits with a total molecular weight of ∽146kDa. Besides functioning as a glycolytic enzyme in cytoplasm, mammalian GAPDH is also involved in a great number of intracellular processes such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication and DNA repair. Recently, findings have been made concerning the role of GAPDH in differentpathologies including prostate cancer progression, programmed neuronal cell death, and age-related neuronal diseases such as Alzheimer’s Disease and Huntington’s Disease. While GAPDH is constitutively expressed in almost all tissues at high levels, there are some physiological factors such as hypoxia and diabetes that increase GAPDH expression in certain cell types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GAPDH
Applications ELISA, Immunoblot, Immunoblot, Immunocytochemistry
Classification Monoclonal
Clone 6C5
Conjugate Unconjugated
Formulation In PBS, pH 7.4.
Host Species Mouse
Immunogen purified, rabbit muscle
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽146kDa GAPDH protein under non-reducing conditions and the ∽36kDa monomeric subunits under reducing conditions.
Target Species Canine, Chicken, Fish, Frog, Human, Mouse, Pig, Rabbit, Rat
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG1
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For Research Use Only

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